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And variable post translational modification in different tissues, facilitating their interactions with their binding partners (cell surface integrins, HA, Ca2+ and collagen). When phosphorylated, they are all highly acidic. The extent of phosphorylation of these proteins and their peptides affects their ability to bind to HA and to regulate mineralization [119]. Modeling of the most frequently ap
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En in the control groups (n = 486) were grouped by the number of years followed, with the prevalence and severity of symptoms calculated both cross-sectionally and longitudinally. Results: About two thirds of the women (67 ) reported vasomotor symptoms and half (46 ) bothersome symptoms at recruitment. In the cross-sectional analysis, their prevalence declined between recruitment and 1-year follow
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