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R calcium ions or hydroxyapatite was verified by circular dichroism, small angle scattering and vibrational spectroscopy (Figure 4). Based on modeling, the phosphorylated peptide folded differently when associated with a model of type I collagen than did the non-phosphorylated peptide (Figure 5). These changes in conformation associated with post-translational modifications, could facilitate nucle
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R calcium ions or hydroxyapatite was verified by circular dichroism, small angle scattering and vibrational spectroscopy (Figure 4). Based on modeling, the phosphorylated peptide folded differently when associated with a model of type I collagen than did the non-phosphorylated peptide (Figure 5). These changes in conformation associated with post-translational modifications, could facilitate nucle
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Orithm. Galectin-1 was ranked at the top of this list. We thus took advantage of our own patient-derived glioblastoma xenograft model [25] in order to further decipher the roles of galectin-1 on GBM cell migration features. The system we have developed mitigates the effect of three important confounders from human samples. First, tissue is frozen within one minute of removal, ensuring high quality
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Between the groups inhaled the leaded gasoline and the control. The GSH content was lower in both the leaded and unleaded gasoline groups than the control group, but GSH in the unleaded group was higher than in the leaded group. The unleaded gasoline exposed group exhibited a significant decrease in superoxide dismutase activity in comparison with either the leaded gasoline or the control groups.
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Ena and facilitated by the conformational flexibility of the chain [131]. These and other atomistic modeling studies suggest the importance of the flexible conformation of the IDPs for interaction with mineral crystals and with collagen [133]. The best demonstration of the importance of IDPs function in the mineralization process comes from studies of animals and people in which IDP has been manip