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Han WT mice both at baseline (-23.3 ) and after 4 hr of infection (-89.53 ), but by the 24 hour time point its levels weremarkedly higher in the SP-A-/- mice (93.8 ), indicating a delayed response in the SP-A-/- mice. c) Potential pathways affected by changes We also used the Ingenuity Systems Pathways Analysis program to better understand the functional implications of the absence of SP-A, both u
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Led feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. Proc Natl Acad Sci U S A 2009, 106:4519?524. Zuidervaart W, van Nieuwpoort F, Stark M, Dijkman R, Packer L, Borgstein AM, Pavey S, van der Velden P, Out C, Jager MJ, et al: Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS. Br
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