DSPP in bone, redundant functions of the protein or differences in the processing of DSPP in bone and dentin [121, 139]. It should be noted that immature Dspp KO mice, contrasted with patients with DSPP mutations, have hypomineralized bones [89]. It is not known whether this is corrected as the mice age. In vitro TEM data suggested that DSPP could induce highly oriented intrafibrillar HA mineraliz